EDITORIALS Anticancer Drug Discovery
نویسنده
چکیده
The National Cancer Institute's (NCI's) human tumor cell line panel for screening potential new anticancer drugs is now operational (/). Its implementation and the demonstration of its feasibility represent a technical and organizational tour de force. The rationale for the change in the primary screen from leukemias in mice to the array of 60 human cancer cell lines was earlier debated in contrasting editorials in this journal (2,3). The new screening panel occupies a central position in the NCI's continued commitment to anticancer drug development (Fig. 1). A major implicit assumption in this schema is the presence of novel, highly active agents among the thousands funnelled into the system. The acquisition of candidate compounds is therefore the initial limiting factor. How did our current complement of 40 or so active anticancer drugs arrive at the first stage of development, and where can we expect future agents to originate?
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